Research Interests
Welcome! We are a basic science research laboratory in the Department of Dermatology, Cell & Developmental Biology and Cellular & Molecular Biology program at the University of Michigan. Our interests are in discovering novel and fundamental insights related to skin and hair follicle biology, epithelial stem cells and cancer.
Our skin is a vital organ of great intrigue due to its immense complexity. Because of this complexity, a multitude of diseases can arise when cellular processes become defective. Some of these diseases are typically mild, such as acne. Others can be disfiguring, such as ichthyosis. Still others, such as basal cell carcinoma (BCC), are fascinating because of their subversion of key developmental pathways such as Hedgehog signaling. All these diseases are related to studies currently ongoing in our lab. In addition, we are keenly interested in studying how hair follicles grow, and how different stem cells in the skin coordinate their behaviors to drive hair regeneration. Our research is generously supported by the NIH, the American Cancer Society, the Leo Foundation, and the Roof cancer research grant.
*** We are hiring! If interested, click here. ***
May 2023
Natalia presented a seminar in Tokyo!
Natalia gave a plenary lecture on sebaceous glands at the annual International Society of Investigative Dermatology (ISID) meeting!
Research Highlights
Hotspots for basal cell carcinoma
Hotspots for basal cell carcinoma
Hotspots for basal cell carcinoma
Where do BCCs come from? Which stem cells in the skin are susceptible to forming tumors? How might nerves play a role?
Sebaceous gland biology
Hotspots for basal cell carcinoma
Hotspots for basal cell carcinoma
Sebaceous glands secrete oils that maintain healthy skin. We study how stem cells that maintain these glands are regulated.
Tumor-drug response
Hotspots for basal cell carcinoma
Tumor-drug response
Advanced BCCs frequently persist after drug treatment. Our study identifies genetic factors that affect tumor-drug response.
How does hair form?
Discovery of Keratin 79
Tumor-drug response
What happens during the earliest stages of hair follicle formation in the skin?
Discovery of Keratin 79
Discovery of Keratin 79
Discovery of Keratin 79
Learn how we identified a novel keratin in the skin, Keratin 79.
Primary cilia & cancer
Discovery of Keratin 79
Discovery of Keratin 79
What does an ancient cellular structure found in pond scum have to do with skin cancer?
Recent Publications
Veniaminova NA*, Jia YY*, Hartigan AM, Huyge TJ, Tsai SY, Grachtchouk M, Nakagawa S, Dlugosz AA, Atwood SX, Wong SY. (*equal contribution)
Cell Reports. 2023 Sep 14; 42:113121.
Trieu KG, Tsai SY, Eberl M, Ju V, Ford NC, Doane OJ, Peterson JK, Veniaminova NA, Grachtchouk M, Harms PW, Swartling FJ, Dlugosz AA, Wong SY.
Cell Reports. 2022 May 3:110779.
Preparing the hair follicle canal for hair shaft emergence.
Mesler AL, Benedeck RE, Wong SY.
Experimental Dermatology. 2021 Apr(4);30:472-478.
Niche-specific factors dynamically regulate sebaceous gland stem cells in the skin.
Veniaminova NA, Grachtchouk M, Doane OJ, Peterson JK, Quigley DA, Lull MV, Pyrozhenko DV, Nair RR, Patrick MT, Balmain A, Dlugosz AA, Tsoi LC, Wong SY.
Developmental Cell. 2019 Nov 4;51:1-15.
Tumor architecture and notch signaling modulate drug response in basal cell carcinoma.
Eberl M, Mangelberger D, Swanson JB, Verhaegen ME, Harms PW, Frohm M, Dlugosz AA, Wong SY.
Cancer Cell. 2018 Feb 12;33(2):229-243.
Loss of Gata6 causes dilation of the hair follicle canal and sebaceous duct.
Swanson JB, Vagnozzi AN, Veniaminova NA, Wong SY.
Experimental Dermatology. 2018 Apr;28(4):345-349.
Mesler AL*, Veniaminova NA*, Lull MV, Wong SY.
Cell Reports. 2017 Apr 25;19(4):809-821. (*equal contribution)
Vagnozzi AN, Reiter JF, Wong SY.
Cell Cycle. 2015;14(21):3408-17.
Peterson SC, Eberl M, Vagnozzi AN, Belkadi A, Veniaminova NA, Verhaegen ME, Bichakjian CK, Ward NL, Dlugosz AA, Wong SY.
Cell Stem Cell. 2015 Apr 2;16(4):400-12.
Veniaminova NA, Vagnozzi AN, Kopinke D, Do TT, Murtaugh LC, Maillard I, Dlugosz AA, Reiter JF, Wong SY.
Development. 2013 Dec;140(24):4870-80.
2009-2011
Wounding mobilizes hair follicle stem cells to form tumors.
Wong SY, Reiter JF.
Proc Natl Acad Sci USA. 2011 Mar 8;108(10):4093-8.
Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis.
Wong SY, Seol AD, So PL, Ermilov AN, Bichakjian CK, Epstein EH Jr, Dlugosz AA, Reiter JF.
Nature Medicine. 2009 Sep;15(9):1055-61.
About Us
Sunny Wong
Natalia Veniaminova
Natalia Veniaminova
Associate Professor, Department of Dermatology, and Cell & Developmental Biology
Natalia Veniaminova
Natalia Veniaminova
Natalia Veniaminova
Research Associate
Sibyl Tsai
Natalia Veniaminova
Matthew Mattoon
Postdoctoral Scholar
Matthew Mattoon
Matthew Mattoon
Matthew Mattoon
Laboratory Technician
Joseph Durgin
Matthew Mattoon
Joseph Durgin
Dermatology Resident
Tom Huyge
Matthew Mattoon
Joseph Durgin
Undergraduate Student
Adrien Hartigan
Stephanie Shimko
Adrien Hartigan
Undergraduate Student
Danielle Gardon
Stephanie Shimko
Adrien Hartigan
Laboratory Technician
Stephanie Shimko
Stephanie Shimko
Stephanie Shimko
Administrative Assistant
Previous Members
Noah Ford, laboratory technician (2021-2023)
Virginia Ju, medical student (2019, 2021)
Rachel Benedeck, laboratory technician (2019-2021)
Kenny Trieu, CDB graduate student (2018-2022) (Ph.D. '22)
Owen Doane, undergraduate research (2017-2021)
Jamie Peterson, laboratory technician (2017-2019)
Jacob Swanson, laboratory technician (2015-2017)
Arlee Mesler, CMB graduate student (2014-2018) (Ph.D. '18)
Madison Lull, undergraduate research (2013-2017)
Markus Eberl, postdoctoral scholar (2012-2017)
Austen Weaver, undergraduate research (2015-2016)
Shelby Peterson-Unsworth, CMB graduate student (2013-2017) (Ph.D. '17)
Nadia Danienta, undergraduate research (2012)
Natalia Veniaminova, postdoctoral scholar (2012- )
Alicia Vagnozzi, laboratory technician (2012-2015)
Karen Myers, administrative aide (2011-2021)
Rotation Students: Takuya Kaneko, Morgan Gingerich, Samantha Devenport, Fatima Javed, Haeyoung Park, LiAng Yao, Ryann Li
Lab Fun