Research Interests

Welcome!  We are a basic science research laboratory in the Department of Dermatology, Cell & Developmental Biology and Cellular & Molecular Biology program at the University of Michigan. Our interests are in discovering novel and fundamental insights related to skin and hair follicle biology, epithelial stem cells and cancer.


Our skin is a vital organ of great intrigue due to its immense complexity. Because of this complexity, a multitude of diseases can arise when cellular processes become defective. Some of these diseases are typically mild, such as acne.  Others can be life-threatening, such as harlequin ichthyosis.  Still others, such as basal cell carcinoma (BCC), are fascinating because of their subversion of key developmental pathways such as Hedgehog signaling.  All these diseases are related to studies currently ongoing in our lab.  In addition, we are keenly interested in studying how hair follicles grow, and how different stem cells in the skin coordinate their behaviors to drive hair regeneration.  Our research is supported by generous funds from the NIH, the American Cancer Society, and the Leo Foundation.


Questions?  Interested in joining the lab?  Click here.

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Recent Publications

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Niche-specific factors dynamically regulate sebaceous gland stem cells in the skin.

Veniaminova  NA, Grachtchouk M, Doane OJ, Peterson JK, Quigley DA, Lull MV,  Pyrozhenko DV, Nair RR, Patrick MT, Balmain A, Dlugosz AA, Tsoi LC, Wong SY.

Developmental Cell.  2019 Nov 4; 51:1-15.


Tumor architecture and notch signaling modulate drug response in basal cell carcinoma.

Eberl M, Mangelberger D, Swanson JB, Verhaegen ME, Harms PW, Frohm M, Dlugosz AA, Wong SY.

Cancer Cell. 2018 Feb 12;33(2):229-243.


Loss of Gata6 causes dilation of the hair follicle canal and sebaceous duct.

Swanson JB, Vagnozzi AN, Veniaminova NA, Wong SY.

Experimental Dermatology. 2018 Apr;28(4):345-349. 


Hair follicle terminal differentiation is orchestrated by distinct early and late matrix progenitors.

Mesler AL, Veniaminova NA, Lull MV, Wong SY.

Cell Reports. 2017 Apr 25;19(4):809-821.


Hair follicle and interfollicular epidermal stem cells make varying contributions to wound regeneration.

Vagnozzi AN, Reiter JF, Wong SY.

Cell Cycle. 2015;14(21):3408-17.


Basal cell carcinoma preferentially arises from stem cells within hair follicle and mechanosensory niches.

Peterson SC, Eberl M, Vagnozzi AN, Belkadi A, Veniaminova NA, Verhaegen ME, Bichakjian CK, Ward NL, Dlugosz AA, Wong SY.

Cell Stem Cell. 2015 Apr 2;16(4):400-12.


Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration.

Veniaminova NA, Vagnozzi AN, Kopinke D, Do TT, Murtaugh LC, Maillard I, Dlugosz AA, Reiter JF, Wong SY.

Development. 2013 Dec;140(24):4870-80.


2009-2011


Wounding mobilizes hair follicle stem cells to form tumors.

Wong SY, Reiter JF.

Proc Natl Acad Sci USA. 2011 Mar 8;108(10):4093-8. 


Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis.

Wong SY, Seol AD, So PL, Ermilov AN, Bichakjian CK, Epstein EH Jr, Dlugosz AA, Reiter JF.

Nature Medicine. 2009 Sep;15(9):1055-61.

About Us

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Sunny Wong

Natalia Veniaminova

Natalia Veniaminova

 Associate Professor, Department of Dermatology, and Cell & Developmental Biology 

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Natalia Veniaminova

Natalia Veniaminova

Natalia Veniaminova

Research Associate

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Kenny Trieu

Natalia Veniaminova

Rachel Benedeck

 Graduate Student, Department of Cell & Developmental Biology  

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Rachel Benedeck

Rachel Benedeck

Rachel Benedeck

Laboratory Technician 

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Virginia Ju

Rachel Benedeck

Virginia Ju

Medical Student

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Owen Doane

Rachel Benedeck

Virginia Ju

Undergraduate Student

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Katie Spencer

Karen Delaney Myers

Karen Delaney Myers

Laboratory Technician

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Karen Delaney Myers

Karen Delaney Myers

Karen Delaney Myers

Administrative Assistant

Previous Trainees

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Kenny Trieu, CDB graduate student (2018- )

Jamie Peterson, laboratory technician (2017-2019)

Arlee Mesler, CMB graduate student (2014-2018) (Ph.D. '18)

Jacob Swanson, laboratory technician (2015-2017)

Markus Eberl, postdoctoral scholar (2012-2017)

Madison Lull, undergraduate research (2013-2017)

Austen Weaver, undergraduate research (2015-2016)

Shelby Peterson-Unsworth, CMB graduate student (2013-2017) (Ph.D. '17)

Nadia Danienta, undergraduate research (2012)

Natalia Veniaminova, postdoctoral scholar (2012- )

Alicia Vagnozzi, laboratory technician (2012-2015)

Rotation Students:  Takuya Kaneko, Morgan Gingerich, Samantha Devenport, Fatima Javed, Haeyoung Park

Lab Fun

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Questions? Interested in joining the lab?

Drop us a line!

We are always looking for talented students and postdocs to join our group.

The Wong Lab @ The University of Michigan